STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DsimGD23855GD23855. (1095 aa)    
Predicted Functional Partners:
Ras85D
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
    
 0.929
DsimGD16638
Phosphodiesterase.
    
 0.919
DsimGD21829
Phosphodiesterase.
    
 0.912
DsimGD22155
Phosphodiesterase.
     
 0.904
DsimGD11781
GD11781; Belongs to the cyclic nucleotide phosphodiesterase family.
     
 0.902
DsimGD22671
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.900
DsimGD12145
GD12145.
     
  0.900
DsimGD22345
GD22345; Belongs to the protein kinase superfamily.
    
 0.852
DsimGD16880
GD16880; Belongs to the protein kinase superfamily.
    
 0.849
DsimGD11572
GD11572.
     
  0.800
Your Current Organism:
Drosophila simulans
NCBI taxonomy Id: 7240
Other names: D. simulans
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.