STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DsimGD23099GD23099; Belongs to the peptidase A1 family. (405 aa)    
Predicted Functional Partners:
DsimGD15875
GD15875; Belongs to the peptidase C1 family.
   
 0.931
DsimGD24324
GD24324.
    
 
 0.838
DsimGD19566
GD19566; Belongs to the peptidase C1 family.
   
 0.833
DsimGD10995
GD10995; Belongs to the peptidase C1 family.
   
 0.832
DsimGD19635
GD19635.
   
 0.702
DsimGD11652
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
      
 0.688
DsimGD25379
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.
      
 0.617
Atg5
Autophagy protein 5; Involved in autophagic vesicle formation.
      
 0.589
DsimGD23074
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
      
 0.582
DsimGD22841
GD22841.
    
 
 0.566
Your Current Organism:
Drosophila simulans
NCBI taxonomy Id: 7240
Other names: D. simulans
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.