STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DvirGJ13251Uncharacterized protein, isoform B. (381 aa)    
Predicted Functional Partners:
Lis-1
Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
    
 
 0.948
DvirGJ13202
CS domain-containing protein.
     
 0.895
DvirGJ11725
CS domain-containing protein.
     
 0.757
DvirGJ15778
Uncharacterized protein, isoform B.
    
 
 0.701
DvirGJ11579
Uncharacterized protein.
     
 0.648
DvirGJ10544
WD_REPEATS_REGION domain-containing protein.
     
 0.627
DvirGJ17271
Uncharacterized protein.
      
 0.600
SAK
Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]
     
 0.591
DvirGJ23171
HAUS6_N domain-containing protein.
     
 0.581
DvirGJ21298
Uncharacterized protein.
    
 
 0.575
Your Current Organism:
Drosophila virilis
NCBI taxonomy Id: 7244
Other names: D. virilis
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