STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgf11SAGA-associated factor 11 homolog; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA- dependent manner. Bind [...] (189 aa)    
Predicted Functional Partners:
DvirGJ22385
SGF29 C-terminal domain-containing protein.
    
 0.992
DvirGJ11383
Ubiquitin carboxyl-terminal hydrolase.
    
 0.990
DvirGJ23060
Transcriptional adapter.
    
 0.980
DvirGJ11336
Uncharacterized protein.
    
 
 0.974
DvirGJ22528
Uncharacterized protein.
    
 0.969
DvirGJ22876
WD_REPEATS_REGION domain-containing protein.
    
 0.969
e(y)2-2
Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...]
   
 0.967
DvirGJ19648
Uncharacterized protein.
    
 0.966
DvirGJ13812
Uncharacterized protein.
    
 0.948
DvirGJ23533
Uncharacterized protein.
    
 0.928
Your Current Organism:
Drosophila virilis
NCBI taxonomy Id: 7244
Other names: D. virilis
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.