STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iHogInterference hedgehog; Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc). Belongs to the immunoglobulin superfamily. IHOG family. (907 aa)    
Predicted Functional Partners:
hh
Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...]
    
 0.996
DvirGJ21830
SSD domain-containing protein.
  
 
 0.990
DvirGJ24666
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 0.633
DvirGJ21665
Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.613
DvirGJ22932
Uncharacterized protein, isoform A.
   
  
 0.583
DvirGJ16643
Uncharacterized protein.
  
0.583
DvirGJ22945
Uncharacterized protein, isoform C.
    
 0.576
DvirGJ15760
Uncharacterized protein, isoform J.
    
0.519
DVIR88_6g0033
Uncharacterized protein.
    
0.519
DvirGJ13689
Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
   
 0.512
Your Current Organism:
Drosophila virilis
NCBI taxonomy Id: 7244
Other names: D. virilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.