Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G001159Blast:E3 ubiquitin-protein ligase Topors. (1096 aa)    
Predicted Functional Partners:
DGUA_6G010923
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.865
DGUA_6G016035
Blast:Modifier of mdg4.
    
 
 0.791
DGUA_6G014549
Blast:Serine/threonine-protein kinase polo.
    
 
 0.756
DGUA_6G012047
Blast:SUMO-conjugating enzyme UBC9-B; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.709
DGUA_6G008743
Blast:SUMO-conjugating enzyme UBC9-A.
    
 0.709
DGUA_6G012616
Blast:SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.709
DGUA_6G008742
Blast:SUMO-conjugating enzyme UBC9.
    
 0.709
DGUA_6G017855
Blast:Protein suppressor of hairy wing.
   
 
 0.708
DGUA_6G007155
Blast:Potassium voltage-gated channel protein Shal; Belongs to the potassium channel family.
      
 0.707
DGUA_6G013712
UBX domain-containing protein 7.
    
   0.695
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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