Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G001254RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (889 aa)    
Predicted Functional Partners:
DGUA_6G016152
Blast:DNA-directed RNA polymerase II subunit RPB7.
    
 0.990
RpII215
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.990
DGUA_6G014419
Blast:DNA-directed RNA polymerase II subunit RPB3.
    
 0.987
DGUA_6G015906
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.986
DGUA_6G016278
General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
    
 0.985
DGUA_6G001959
Blast:Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily.
    
 0.975
DGUA_6G011687
Blast:Restin homolog.
    
 0.967
DGUA_6G013398
Blast:Transcription initiation factor IIB.
    
 
 0.957
DGUA_6G018525
Blast:DNA-directed RNA polymerases I, II, and III subunit RPABC2.
   
 0.951
DGUA_6G018380
Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.
   
 0.951
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (20%) [HD]