Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G003077Blast:Sprouty-related, EVH1 domain-containing protein 2. (421 aa)    
Predicted Functional Partners:
DGUA_6G020241
Blast:Neurofibromin.
    
 0.837
DGUA_6G020240
Blast:Neurofibromin.
    
 0.837
DGUA_6G010399
Non-specific serine/threonine protein kinase.
    
   0.808
DGUA_6G011174
Blast:Ras-associated and pleckstrin homology domains-containing protein 1.
    
 0.789
DGUA_6G004703
Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
   
 0.769
DGUA_6G009462
Blast:Tyrosine-protein kinase Abl.
    
 0.756
DGUA_6G018141
Blast:Bromodomain and WD repeat-containing protein 1.
      
 0.742
DGUA_6G007264
Blast:Nuclear envelope phosphatase-regulatory subunit 1 homolog.
      
 0.724
DGUA_6G007930
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 
 0.713
DGUA_6G016686
Blast:Centromere protein J.
      
 0.699
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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