Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G003331Blast:Probable cytochrome P450 6a14; Belongs to the cytochrome P450 family. (509 aa)    
Predicted Functional Partners:
DGUA_6G006215
CLIP domain-containing serine protease; Belongs to the peptidase S1 family. CLIP subfamily.
    
   0.869
DGUA_6G001903
Uncharacterized protein.
    
  0.846
DGUA_6G008735
Blast:Protein LST8 homolog.
   
  0.821
DGUA_6G012822
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.
   
   0.810
DGUA_6G004301
Blast:Immunoglobulin-binding protein 1.
    
   0.810
DGUA_6G016414
Blast:NuA4 complex subunit EAF3 homolog.
    
   0.644
DGUA_6G006538
Blast:Ecdysone 20-monooxygenase; Belongs to the cytochrome P450 family.
  
 
 0.554
MED4
Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.510
DGUA_6G015551
Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.510
DGUA_6G019863
Blast:Cytochrome P450 307a1; Belongs to the cytochrome P450 family.
  
 0.507
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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