Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
DGUA_6G006686Cell cycle checkpoint control protein; Belongs to the rad9 family. (458 aa)    
Predicted Functional Partners:
DGUA_6G013639
Blast:Cell cycle checkpoint protein RAD1.
    
 0.999
DGUA_6G017186
Checkpoint protein; Belongs to the HUS1 family.
    
 0.999
DGUA_6G005241
Blast:Cell cycle checkpoint protein RAD17.
   
 0.996
DGUA_6G010676
Blast:DNA topoisomerase 2-binding protein 1.
    
 0.992
DGUA_6G000272
Blast:Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.990
DGUA_6G008112
Blast:Replication factor C subunit 2.
   
 0.982
DGUA_6G016431
Blast:Serine/threonine-protein kinase ATM; Belongs to the PI3/PI4-kinase family.
    
 0.982
DGUA_6G010204
Blast:Transcription initiation factor TFIID subunit 9.
   
 0.978
DGUA_6G017558
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.976
DGUA_6G012330
Blast:Replication factor C subunit 3.
   
 0.961
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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