Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G003258Blast:Leucine-rich repeat-containing protein 16A. (1493 aa)    
Predicted Functional Partners:
DGUA_6G014140
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
 0.925
DGUA_6G002551
F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
 0.897
DGUA_6G017010
Blast:Tight junction protein ZO-1; Belongs to the MAGUK family.
   
  
 0.775
DGUA_6G000407
Blast:Caspase-1; Belongs to the peptidase C14A family.
      
 0.771
DGUA_6G005254
Blast:Actin-related protein 1.
    
 
 0.723
DGUA_6G006999
Blast:Dynactin subunit 1.
    
   0.712
DGUA_6G010226
Uncharacterized protein.
    
 0.668
DGUA_6G007151
Blast:Dynactin subunit 1.
    
   0.563
DGUA_6G009009
Blast:BTB/POZ domain-containing protein KCTD5.
      
 0.549
DGUA_6G000353
Blast:Myeloid differentiation primary response protein MyD88.
      
 0.546
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.