Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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DGUA_6G010391Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1834 aa)    
Predicted Functional Partners:
DGUA_6G001057
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.995
DGUA_6G001334
Blast:Inositol-pentakisphosphate 2-kinase.
     
 0.986
DGUA_6G003847
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
   0.889
DGUA_6G006856
Blast:Teneurin-m.
     
  0.852
DGUA_6G000882
Blast:H/ACA ribonucleoprotein complex subunit 4.
    
 
 0.834
DGUA_6G009092
Uncharacterized protein.
      
 0.830
DGUA_6G014986
Uncharacterized protein.
      
 0.815
DGUA_6G003616
Blast:Periodic tryptophan protein 1 homolog.
    
   0.805
DGUA_6G005591
Blast:Tenascin-R.
     
  0.805
DGUA_6G001916
Blast:Vacuolar protein-sorting-associated protein 25.
     
  0.752
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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