STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G007806Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (292 aa)    
Predicted Functional Partners:
DGUA_6G007359
Blast:General transcription factor IIE subunit 1.
   
 0.999
DGUA_6G001743
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
   
 0.996
DGUA_6G007261
Blast:DNA excision repair protein haywire.
    
 0.996
DGUA_6G016278
General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
   
 0.995
DGUA_6G009792
General transcription factor IIH subunit.
   
 0.995
DGUA_6G002037
Blast:TFIIH basal transcription factor complex helicase XPD subunit.
    
 0.994
DGUA_6G002421
Blast:General transcription factor IIH subunit 1.
    
 0.992
DGUA_6G006649
Blast:Cyclin-H; Belongs to the cyclin family.
    
 0.992
DGUA_6G020285
General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.
    
 0.992
DGUA_6G013398
Blast:Transcription initiation factor IIB.
    
 0.991
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.