Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (662 aa)    
Predicted Functional Partners:
DGUA_6G010620
Blast:DNA replication ATP-dependent helicase/nuclease DNA2.
   
 
 0.977
DGUA_6G007171
Blast:Histone chaperone asf1.
   
 
 0.960
DGUA_6G005916
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.
 
 
 
 0.947
DGUA_6G000272
Blast:Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
   
 
 0.919
DGUA_6G015699
Blast:Protein timeless homolog.
    
 
 0.918
DGUA_6G002791
Blast:DNA repair protein RAD50.
   
 
 0.912
DGUA_6G004998
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
  
 
 0.910
DGUA_6G019357
Blast:Crossover junction endonuclease MUS81.
   
 
 0.908
DGUA_6G019939
Blast:Bloom syndrome protein homolog.
  
 
 0.902
DGUA_6G000762
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.901
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.