Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G012530Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1028 aa)    
Predicted Functional Partners:
DGUA_6G005490
Blast:CTL-like protein 2.
    
 0.970
DGUA_6G007171
Blast:Histone chaperone asf1.
    
 0.968
DGUA_6G006518
Blast:Transcription factor GAGA.
    
   0.807
DGUA_6G005229
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.802
Caf1
Blast:Probable histone-binding protein Caf1.
    
 
 0.698
DGUA_6G016763
Blast:Probable histone-binding protein Caf1.
    
 
 0.698
DGUA_6G010195
Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.
    
   0.625
DGUA_6G001694
Blast:Chromatin assembly factor 1 subunit B.
    
 
 0.619
DGUA_6G001283
Blast:Histone H3-like centromeric protein cid.
    
 0.611
DGUA_6G021251
Histone H3; Belongs to the histone H3 family.
    
 0.611
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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