Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G012631Kinase; Belongs to the inositol phosphokinase (IPK) family. (339 aa)    
Predicted Functional Partners:
DGUA_6G001334
Blast:Inositol-pentakisphosphate 2-kinase.
     
 0.994
DGUA_6G020082
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
    
 0.989
DGUA_6G010302
Blast:Multiple inositol polyphosphate phosphatase 1.
     
 0.984
DGUA_6G009438
Blast:Multiple inositol polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family.
     
 0.984
DGUA_6G018081
Blast:Type I inositol 1,4,5-trisphosphate 5-phosphatase.
     
 0.983
DGUA_6G004157
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.980
DGUA_6G019685
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
 0.978
DGUA_6G012578
Phosphoinositide phospholipase C.
     
  0.977
DGUA_6G020648
Blast:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A.
     
 0.959
DGUA_6G011349
Uncharacterized protein.
     
 0.953
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.