Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G005014Blast:Nicastrin. (699 aa)    
Predicted Functional Partners:
DGUA_6G003783
Blast:Gamma-secretase subunit pen-2.
    
 0.999
DGUA_6G007782
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.999
DGUA_6G013595
Blast:Gamma-secretase subunit Aph-1.
   
 0.999
DGUA_6G018764
Blast:Neurogenic locus Notch protein.
    
 0.997
DGUA_6G005485
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 0.944
DGUA_6G010843
Blast:Beta-amyloid-like protein.
    
 0.845
DGUA_6G017666
Blast:Disintegrin and metalloproteinase domain-containing protein 10.
    
 
 0.843
DGUA_6G014151
Blast:Disintegrin and metalloproteinase domain-containing protein 10.
    
 
 0.843
DGUA_6G004458
Blast:Protein numb.
      
 0.818
DGUA_6G001477
Blast:Kunitz-type serine protease inhibitor textilinin-3.
    
 0.725
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (22%) [HD]