Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G005886Blast:Lysosomal acid phosphatase; Belongs to the histidine acid phosphatase family. (469 aa)    
Predicted Functional Partners:
DGUA_6G005174
Blast:Low molecular weight phosphotyrosine protein phosphatase 1.
     
 0.978
DGUA_6G016563
Blast:Putative riboflavin kinase.
     
  0.977
DGUA_6G017708
Blast:Lysosomal acid phosphatase; Belongs to the histidine acid phosphatase family.
     
  0.977
DGUA_6G015555
Blast:Flavin reductase (NADPH).
     
  0.977
DGUA_6G005173
Blast:Low molecular weight phosphotyrosine protein phosphatase 1.
     
  0.924
DGUA_6G005172
Blast:Low molecular weight phosphotyrosine protein phosphatase 2.
     
  0.924
DGUA_6G019502
Blast:FAD synthase.
     
  0.924
DGUA_6G004349
Blast:FAD synthase.
     
  0.924
DGUA_6G006692
tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.
     
  0.752
DGUA_6G010923
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
     
  0.724
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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