Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G005941Blast:Lethal(3)malignant brain tumor-like protein 3. (1186 aa)    
Predicted Functional Partners:
DGUA_6G008793
Uncharacterized protein.
   
 0.917
Sce
Blast:E3 ubiquitin-protein ligase RING1.
    
 0.766
DGUA_6G014461
Uncharacterized protein.
   
 0.751
DGUA_6G016388
Blast:Transcription factor E2f.
    
 0.748
DGUA_6G000246
Blast:YY1-associated factor 2.
    
 0.728
DGUA_6G005229
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.719
Pc
Blast:Polycomb group protein Pc.
    
 0.715
Sfmbt
Blast:Polycomb protein Sfmbt.
    
 0.685
DGUA_6G013967
Blast:Transcription factor E2F2.
    
 0.684
DGUA_6G009028
Blast:Pentraxin-related protein PTX3.
    
 0.681
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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