Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G006087Histone H2A; Belongs to the histone H2A family. (141 aa)    
Predicted Functional Partners:
DGUA_6G005229
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.987
DGUA_6G009853
Blast:Histone acetyltransferase KAT2A.
    
 0.979
DGUA_6G021251
Histone H3; Belongs to the histone H3 family.
   
 0.976
DGUA_6G003839
Blast:Chromatin-remodeling complex ATPase chain Iswi.
   
 0.975
DGUA_6G007171
Blast:Histone chaperone asf1.
 
 
 
 0.971
DGUA_6G015449
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
   
 0.971
DGUA_6G011756
Blast:Coiled-coil domain-containing protein 170.
    
 0.966
DGUA_6G016414
Blast:NuA4 complex subunit EAF3 homolog.
   
 0.963
DGUA_6G014744
Blast:FACT complex subunit spt16.
    
 
 0.962
DGUA_6G005624
Blast:Vacuolar protein sorting-associated protein 72 homolog.
    
 
 0.962
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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