Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
DGUA_6G012733Blast:Protein purity of essence. (5393 aa)    
Predicted Functional Partners:
DGUA_6G011247
Blast:E3 ubiquitin-protein ligase HUWE1.
   
 
 0.822
DGUA_6G017203
Blast:Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.795
DGUA_6G010702
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.793
DGUA_6G016516
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.701
DGUA_6G014367
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.697
DGUA_6G004752
ZZ-type domain-containing protein.
    
 
 0.697
DGUA_6G018737
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.697
DGUA_6G018722
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.697
DGUA_6G018742
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.697
DGUA_6G020162
Blast:E3 ubiquitin-protein ligase KCMF1.
    
 
 0.697
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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