Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G002753Fanconi_A_N domain-containing protein. (380 aa)    
Predicted Functional Partners:
DGUA_6G005304
Blast:E3 ubiquitin-protein ligase FANCL.
    
 0.954
DGUA_6G007322
Blast:60S ribosomal protein L10a-2.
   
 0.932
DGUA_6G017870
Blast:Fanconi anemia group D2 protein.
   
 0.909
DGUA_6G000915
Blast:Fanconi anemia group I protein homolog.
   
 0.900
DGUA_6G017558
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.849
DGUA_6G019641
GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.
   
 
 0.848
DGUA_6G002004
Blast:DNA excision repair protein ERCC-1.
   
 0.825
DGUA_6G020592
Blast:Nuclear pore complex protein Nup153.
    
 
 0.816
DGUA_6G012934
Blast:Ubiquitin-conjugating enzyme E2 E3.
   
 0.814
DGUA_6G000917
Blast:Nuclear pore glycoprotein p62.
    
 
 0.810
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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