Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G005259Blast:Kanadaptin. (2231 aa)    
Predicted Functional Partners:
DGUA_6G005916
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.
  
 
 0.882
DGUA_6G008720
Blast:DNA ligase 4; Belongs to the ATP-dependent DNA ligase family.
  
 
 0.879
DGUA_6G017870
Blast:Fanconi anemia group D2 protein.
   
 0.878
DGUA_6G004891
Blast:DNA repair protein complementing XP-G cells homolog.
  
 
 0.835
DGUA_6G018545
Blast:Protein FAM60A.
      
 0.815
Fen1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 
 0.796
DGUA_6G002791
Blast:DNA repair protein RAD50.
  
 
 0.779
DGUA_6G002004
Blast:DNA excision repair protein ERCC-1.
     
 0.751
DGUA_6G001978
Blast:DNA polymerase zeta catalytic subunit.
   
 
 0.727
DGUA_6G019357
Blast:Crossover junction endonuclease MUS81.
   
 
 0.724
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: medium (52%) [HD]