Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G000879Blast:Ubiquitin-protein ligase E3C. (1124 aa)    
Predicted Functional Partners:
DGUA_6G013684
Blast:26S proteasome non-ATPase regulatory subunit 14.
    
 
 0.938
DGUA_6G007930
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
    
 
 0.932
DGUA_6G009742
Blast:26S proteasome non-ATPase regulatory subunit 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 
 0.927
DGUA_6G015151
Blast:Polyubiquitin.
    
 0.834
DGUA_6G008901
Blast:Polyubiquitin.
    
 0.834
DGUA_6G006198
Blast:Ubiquitin-like domain-containing CTD phosphatase 1.
    
 
 0.794
DGUA_6G012934
Blast:Ubiquitin-conjugating enzyme E2 E3.
    
 0.782
DGUA_6G013302
Ubiquitin carboxyl-terminal hydrolase.
    
 
 0.768
DGUA_6G012794
Blast:Ubiquitin-conjugating enzyme E2 2.
    
 0.749
DGUA_6G015955
Blast:26S proteasome non-ATPase regulatory subunit 6.
   
 
 0.730
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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