Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G018381Blast:EF-hand domain-containing protein D2 homolog. (392 aa)    
Predicted Functional Partners:
DGUA_6G001033
Blast:Spermatogenesis-associated protein 17.
   
   0.760
DGUA_6G013922
Blast:Protein phosphatase inhibitor 2.
   
    0.751
DGUA_6G014048
Uncharacterized protein.
   
    0.749
DGUA_6G013546
Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
   
 
 0.732
DGUA_6G004755
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
   
   0.684
DGUA_6G004669
Blast:Cytochrome c oxidase subunit 6A1, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family.
   
    0.606
DGUA_6G004668
Blast:Cytochrome c oxidase subunit 6A1, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family.
   
    0.606
DGUA_6G010153
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
   0.597
DGUA_6G011757
Blast:Actin-related protein 2; Belongs to the actin family.
   
   0.597
DGUA_6G013999
Blast:Putative elongator complex protein 4.
    
   0.568
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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