Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G017719Blast:Peripheral plasma membrane protein CASK; Belongs to the MAGUK family. (907 aa)    
Predicted Functional Partners:
DGUA_6G012382
Blast:Disks large homolog 5.
   
 0.997
Urm1
Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxid [...]
    
 0.997
DGUA_6G015949
Blast:Neurexin-3.
    
 0.992
DGUA_6G015585
Blast:Glutamate receptor ionotropic, kainate 2.
    
 0.991
DGUA_6G009123
Blast:Protein lin-10.
   
 0.975
DGUA_6G020001
Blast:Protein lin-10.
   
 0.975
DGUA_6G021128
Uncharacterized protein.
   
 0.975
DGUA_6G021149
Blast:Protein lin-10.
   
 0.975
DGUA_6G015357
Blast:Regulating synaptic membrane exocytosis protein 2.
   
 0.971
DGUA_6G011334
Blast:Synaptotagmin-like protein 1.
   
 0.958
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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