Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G017908Hermansky-Pudlak syndrome 5 protein homolog; Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes. (831 aa)    
Predicted Functional Partners:
DGUA_6G006931
Uncharacterized protein.
   
 
 0.951
DGUA_6G000720
Blast:Hermansky-Pudlak syndrome 4 protein.
      
 0.819
DGUA_6G006682
Blast:Dysbindin protein homolog.
      
 0.747
DGUA_6G007296
Blast:Vitamin K-dependent gamma-carboxylase.
      
 0.701
DGUA_6G007357
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis.
      
 0.699
DGUA_6G004011
Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.
   
 
 0.646
DGUA_6G010677
AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.
    
 
 0.599
DGUA_6G015379
Blast:Biogenesis of lysosome-related organelles complex 1 subunit 2.
    
 
 0.561
DGUA_6G003357
Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
      
 0.554
DGUA_6G016956
Blast:GTP-binding protein Rheb homolog.
      
 0.553
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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