Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G010499Histone H2B; Belongs to the histone H2B family. (126 aa)    
Predicted Functional Partners:
DGUA_6G005229
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.979
DGUA_6G021251
Histone H3; Belongs to the histone H3 family.
 
 
 0.965
DGUA_6G013685
Histone H3; Belongs to the histone H3 family.
 
 
 0.924
DGUA_6G021279
Histone H2A; Belongs to the histone H2A family.
 
 0.898
DGUA_6G006087
Histone H2A; Belongs to the histone H2A family.
   
 0.897
DGUA_6G021248
Histone H2A; Belongs to the histone H2A family.
  
 0.893
DGUA_6G007987
E3 ubiquitin protein ligase.
    
 0.886
DGUA_6G001283
Blast:Histone H3-like centromeric protein cid.
   
 0.884
DGUA_6G017203
Blast:Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.883
DGUA_6G013333
Blast:Ubiquitin-40S ribosomal protein S27a.
   
 0.878
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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