Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
DGUA_6G018420Blast:NEDD8 ultimate buster 1. (588 aa)    
Predicted Functional Partners:
DGUA_6G012258
Blast:NEDD8.
    
 0.974
DGUA_6G004258
Blast:Actin-binding protein IPP.
    
   0.965
DGUA_6G000734
Blast:Myosin light chain kinase, smooth muscle.
    
   0.964
DGUA_6G009742
Blast:26S proteasome non-ATPase regulatory subunit 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.878
DGUA_6G007930
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
    
 0.820
DGUA_6G018997
Blast:AH receptor-interacting protein.
    
 
 0.806
DGUA_6G016629
Uncharacterized protein.
      
 0.772
DGUA_6G000852
Blast:STE20-like serine/threonine-protein kinase.
    
 0.749
DGUA_6G003069
Blast:26S proteasome non-ATPase regulatory subunit 11.
    
 0.744
DGUA_6G003597
Blast:26S protease regulatory subunit 7; Belongs to the AAA ATPase family.
    
  0.723
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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