Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G010676Blast:DNA topoisomerase 2-binding protein 1. (1437 aa)    
Predicted Functional Partners:
DGUA_6G010113
Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
   
 0.996
DGUA_6G006686
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.992
DGUA_6G000272
Blast:Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.989
DGUA_6G005241
Blast:Cell cycle checkpoint protein RAD17.
   
 0.978
DGUA_6G019341
Blast:Cell division control protein 45 homolog.
   
 
 0.973
DGUA_6G009887
Blast:Nibrin.
    
 0.972
DGUA_6G020219
DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.
    
 
 0.971
DGUA_6G016431
Blast:Serine/threonine-protein kinase ATM; Belongs to the PI3/PI4-kinase family.
   
 0.968
DGUA_6G004998
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 
 0.965
DGUA_6G017186
Checkpoint protein; Belongs to the HUS1 family.
    
 0.964
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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