STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G016322Ubiquitin carboxyl-terminal hydrolase. (903 aa)    
Predicted Functional Partners:
DGUA_6G014889
Blast:E3 ubiquitin-protein ligase NRDP1.
    
 0.954
DGUA_6G014160
Blast:E3 ubiquitin-protein ligase NRDP1.
    
 0.954
DGUA_6G013333
Blast:Ubiquitin-40S ribosomal protein S27a.
    
 0.946
DGUA_6G003161
Receptor protein-tyrosine kinase.
    
 0.945
DGUA_6G015274
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
     
 0.923
DGUA_6G013463
Blast:Signal transducing adapter molecule 1.
    
 0.908
DGUA_6G011881
Blast:Ubiquitin-60S ribosomal protein L40.
   
 0.903
DGUA_6G015151
Blast:Polyubiquitin.
   
 0.859
DGUA_6G008901
Blast:Polyubiquitin.
   
 0.859
DGUA_6G013613
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
   
 0.821
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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