Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DGUA_6G007177Blast:E3 ubiquitin-protein ligase rnf146. (442 aa)    
Predicted Functional Partners:
DGUA_6G018449
Poly [ADP-ribose] polymerase.
    
 0.992
DGUA_6G005904
Blast:Axin.
    
 0.968
DGUA_6G011057
Blast:Protein DENND6B.
    
 
 0.938
DGUA_6G005369
DNA ligase.
    
 
 0.933
DGUA_6G014744
Blast:FACT complex subunit spt16.
    
   0.923
DGUA_6G019846
Poly [ADP-ribose] polymerase.
    
 
 0.919
DGUA_6G003797
Blast:DNA repair protein complementing XP-C cells homolog.
    
   0.916
DGUA_6G003847
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 
 0.816
DGUA_6G013359
Blast:Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein.
    
 0.690
DGUA_6G013333
Blast:Ubiquitin-40S ribosomal protein S27a.
    
  0.689
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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