STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G003936DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1468 aa)    
Predicted Functional Partners:
DGUA_6G010923
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.976
DGUA_6G003111
Structural maintenance of chromosomes protein.
   
 
 0.949
DGUA_6G019692
Blast:BTB/POZ domain-containing protein KCTD9.
   
 
 0.930
DGUA_6G004984
Blast:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L.
    
 0.918
DGUA_6G014122
Structural maintenance of chromosomes protein.
   
 
 0.888
DGUA_6G017425
Blast:Structural maintenance of chromosomes protein 6.
   
 
 0.887
DGUA_6G004554
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.883
DGUA_6G015985
Blast:Baculoviral IAP repeat-containing protein 5.
   
  
 0.880
DGUA_6G009847
Blast:Ubiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.858
DGUA_6G014588
Blast:Bipolar kinesin KRP-130; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.855
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.