STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DGUA_6G005229Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)    
Predicted Functional Partners:
DGUA_6G017970
Histone acetyltransferase type B catalytic subunit.
    
 0.998
DGUA_6G006087
Histone H2A; Belongs to the histone H2A family.
 
 
 0.996
DGUA_6G007171
Blast:Histone chaperone asf1.
    
 
 0.992
DGUA_6G009853
Blast:Histone acetyltransferase KAT2A.
    
 0.986
DGUA_6G003839
Blast:Chromatin-remodeling complex ATPase chain Iswi.
   
 0.982
DGUA_6G017025
Blast:PHD finger protein 20-like protein 1.
   
 0.980
DGUA_6G014744
Blast:FACT complex subunit spt16.
    
 
 0.979
DGUA_6G003847
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 
 0.978
DGUA_6G013685
Histone H3; Belongs to the histone H3 family.
 
 
 0.978
DGUA_6G014550
Blast:Retinoblastoma-binding protein 5 homolog.
    
 0.971
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.