STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D0Z67_26915Unannotated protein; Belongs to the TPP enzyme family. (575 aa)    
Predicted Functional Partners:
D0Z67_20675
Unannotated protein.
 
 0.998
leuD
Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.926
ilvC
Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.925
leuC
Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.914
D0Z67_20735
Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.899
D0Z67_16965
Unannotated protein.
  
 
 0.893
ackA
Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.885
leuA
Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.871
D0Z67_27740
Unannotated protein.
  
 
 0.870
D0Z67_10175
Unannotated protein; Belongs to the TPP enzyme family.
  
  
0.866
Your Current Organism:
Streptomyces seoulensis
NCBI taxonomy Id: 73044
Other names: CIP 105312, IFO 16255, IFO 16668, IMSNU 21266, JCM 10116, NBRC 16255, NBRC 16668, S. seoulensis, Streptomyces sp. USC028, Streptomyces sp. USC046, strain IMSNU-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.