Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rseCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)    
Predicted Functional Partners:
rseB
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.995
rseA
Transcriptional regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish d [...]
 
  
 0.862
rnfG
Electron transporter RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
 
     0.648
rpoE
RNA polymerase subunit sigma; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
  
  
 0.600
rnfC_1
Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
 
   
 0.578
mobB
Molybdopterin-guanine dinucleotide biosynthesis protein B; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.569
hsrA_2
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.541
rnfD
Electron transporter RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.
 
   
 0.514
ygfY
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.493
rnfA
Electron transporter RsxA; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
   
 0.438
Your Current Organism:
Aggregatibacter aphrophilus
NCBI taxonomy Id: 732
Other names: A. aphrophilus, ATCC 29241 [[Haemophilus paraphrophilus]], ATCC 33389, CCUG 3715, CCUG 41355 [[Haemophilus paraphrophilus]], CIP 70.72 [[Haemophilus paraphrophilus]], CIP 70.73, Haemophilus aphrophilus, Haemophilus paraphrophilus, NCTC 10557 [[Haemophilus paraphrophilus]], NCTC 5906
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.