Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rseBTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)    
Predicted Functional Partners:
rseA
Transcriptional regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish d [...]
 
 
 0.998
rseC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.995
rpoE
RNA polymerase subunit sigma; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.876
AKU64313.1
SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.710
AKU63083.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.633
AKU62384.1
HemX protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.621
seqA_2
Negative modulator of the initiation of chromosome replication; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.617
lptC
Sugar transporter; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.608
AKU62563.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0352 family.
  
     0.600
yecM
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.596
Your Current Organism:
Aggregatibacter aphrophilus
NCBI taxonomy Id: 732
Other names: A. aphrophilus, ATCC 29241 [[Haemophilus paraphrophilus]], ATCC 33389, CCUG 3715, CCUG 41355 [[Haemophilus paraphrophilus]], CIP 70.72 [[Haemophilus paraphrophilus]], CIP 70.73, Haemophilus aphrophilus, Haemophilus paraphrophilus, NCTC 10557 [[Haemophilus paraphrophilus]], NCTC 5906
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