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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrD_2Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 0.988
AKU63797.1
Carbamoyl-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.899
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.896
pheT
phenylalanine--tRNA ligase; Catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.841
carB
Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.828
AKU63703.1
S-adenosylmethionine tRNA ribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.770
AKU63704.1
Peptidase S51; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.757
AKU63306.1
Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.731
pyrR
Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.672
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.643
Your Current Organism:
Aggregatibacter aphrophilus
NCBI taxonomy Id: 732
Other names: A. aphrophilus, ATCC 29241 [[Haemophilus paraphrophilus]], ATCC 33389, CCUG 3715, CCUG 41355 [[Haemophilus paraphrophilus]], CIP 70.72 [[Haemophilus paraphrophilus]], CIP 70.73, Haemophilus aphrophilus, Haemophilus paraphrophilus, NCTC 10557 [[Haemophilus paraphrophilus]], NCTC 5906
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