GX50_00672 protein (Emmonsia crescens) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

GX50_00672

Methyltranfer_dom domain-containing protein. (281 aa)

Predicted Functional Partners:

GX50_05070

0.621

GX50_00416

0.617

GX50_07333

0.602

GX50_03146

0.599

GX50_00311

0.599

RPS1

0.598

GX50_00539

0.598

GX50_05234

0.596

GX50_02332

0.594

GX50_00248

0.594

Your Current Organism:

Emmonsia crescens

NCBI taxonomy Id: 73230
Other names: ATCC 13704, Ajellomyces crescens, CBS 177.60, Chrysosporium parvum var. crescens, E. crescens, Emmonsia parva var. crescens, UAMH 3008

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GX50_00248	GX50_00311	A0A2B7ZVI3	A0A2B7ZUJ1	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999
GX50_00248	GX50_00416	A0A2B7ZVI3	A0A2B7ZRV2	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Pre-rRNA-processing protein TSR1.	0.982
GX50_00248	GX50_00539	A0A2B7ZVI3	A0A2B7ZV94	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family.	0.990
GX50_00248	GX50_00672	A0A2B7ZVI3	A0A2B7ZS55	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Methyltranfer_dom domain-containing protein.	0.594
GX50_00248	GX50_02332	A0A2B7ZVI3	A0A2B7ZNM0	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S27.	0.999
GX50_00248	GX50_03146	A0A2B7ZVI3	A0A2B7ZLE3	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.999
GX50_00248	GX50_05070	A0A2B7ZVI3	A0A2B7ZFM2	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Essential nuclear protein 1.	0.993
GX50_00248	GX50_07333	A0A2B7ZVI3	A0A2B7Z8L3	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	Protein LTV1.	0.993
GX50_00248	RPS1	A0A2B7ZVI3	A0A2B7Z9W8	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
GX50_00311	GX50_00248	A0A2B7ZUJ1	A0A2B7ZVI3	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
GX50_00311	GX50_00416	A0A2B7ZUJ1	A0A2B7ZRV2	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Pre-rRNA-processing protein TSR1.	0.989
GX50_00311	GX50_00539	A0A2B7ZUJ1	A0A2B7ZV94	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family.	0.988
GX50_00311	GX50_00672	A0A2B7ZUJ1	A0A2B7ZS55	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Methyltranfer_dom domain-containing protein.	0.599
GX50_00311	GX50_02332	A0A2B7ZUJ1	A0A2B7ZNM0	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S27.	0.999
GX50_00311	GX50_03146	A0A2B7ZUJ1	A0A2B7ZLE3	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.999
GX50_00311	GX50_05070	A0A2B7ZUJ1	A0A2B7ZFM2	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Essential nuclear protein 1.	0.995
GX50_00311	GX50_07333	A0A2B7ZUJ1	A0A2B7Z8L3	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Protein LTV1.	0.991
GX50_00311	RPS1	A0A2B7ZUJ1	A0A2B7Z9W8	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
GX50_00416	GX50_00248	A0A2B7ZRV2	A0A2B7ZVI3	Pre-rRNA-processing protein TSR1.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.982
GX50_00416	GX50_00311	A0A2B7ZRV2	A0A2B7ZUJ1	Pre-rRNA-processing protein TSR1.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.989

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Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.914

expected number of edges:

15

PPI enrichment p-value:

6.1e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031564

Transcription antitermination

3 of 5

2.37

2.19

6.93e-05

GO:0006353

DNA-templated transcription, termination

3 of 5

2.37

2.19

6.93e-05

GO:0035999

Tetrahydrofolate interconversion

3 of 10

2.07

1.83

0.00025

GO:0000105

Histidine biosynthetic process

3 of 16

1.86

1.57

0.00059

GO:0009086

Methionine biosynthetic process

3 of 22

1.72

1.4

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004488

Methylenetetrahydrofolate dehydrogenase (NADP+) activity

3 of 3

2.59

2.04

0.00017

GO:0004477

Methenyltetrahydrofolate cyclohydrolase activity

3 of 3

2.59

2.04

0.00017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 338

0.84

0.57

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:958

Folic acid-containing compound metabolic process, and Deoxyribonucleotide biosynthetic process

4 of 18

1.94

1.85

0.00016

CL:861

Mixed, incl. Nucleoside monophosphate metabolic process, and Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

5 of 82

1.37

1.24

0.00061

CL:978

Tetrahydrofolate interconversion

2 of 5

2.19

0.88

0.0235

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

4 of 26

1.78

1.88

7.53e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0889

Transcription antitermination

3 of 3

2.59

2.31

5.08e-05

KW-0554

One-carbon metabolism

3 of 8

2.16

1.9

0.00021

KW-0486

Methionine biosynthesis

3 of 10

2.07

1.83

0.00024

KW-0511

Multifunctional enzyme

3 of 11

2.03

1.82

0.00024

KW-0658

Purine biosynthesis

3 of 15

1.89

1.65

0.00041

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

2.05

0.00016

PF00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

2.05

0.00016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020631

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

3 of 3

2.59

1.84

0.00040

IPR020630

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

3 of 3

2.59

1.84

0.00040

IPR000672

Tetrahydrofolate dehydrogenase/cyclohydrolase

3 of 3

2.59

1.84

0.00040

IPR046346

Aminoacid dehydrogenase-like, N-terminal domain superfamily

3 of 6

2.29

1.78

0.00042

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