Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fecDIron-dicitrate transporter subunit FecD; Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter; Derived by automated computational an [...] (327 aa)    
Predicted Functional Partners:
fecB
Iron-dicitrate transporter substrate-binding subunit; Part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
OOR95248.1
Ferric citrate ABC transporter ATP-binding protein FecE; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
OOR96598.1
Heme ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.904
fecC
Iron-dicitrate transporter permease subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
  
 
0.898
OOR94865.1
Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.682
OOR94392.1
Helical backbone metal receptor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.628
OOR95275.1
Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
  
 
0.599
OOR95246.1
Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.586
OOR95247.1
Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.586
OOR95825.1
Iron-regulated outer membrane virulence protein; Iron-responsive element (ireA); ireA gene is located on pathogenicity island I (PAI I); outer membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.423
Your Current Organism:
Haemophilus paraphrohaemolyticus
NCBI taxonomy Id: 736
Other names: ATCC 29237, CCUG 3718, CIP 102512, DSM 21451, H. paraphrohaemolyticus, NCTC 10670
Server load: medium (46%) [HD]