STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FF38_05673PKD_channel domain-containing protein. (669 aa)    
Predicted Functional Partners:
FF38_13878
Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.724
FF38_11246
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.717
FF38_12881
Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.702
FF38_07260
RGS domain-containing protein.
     
 0.701
FF38_14393
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.636
FF38_05821
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
      
 0.601
FF38_10899
Uncharacterized protein.
   
  
 0.508
FF38_14362
V-type proton ATPase subunit H.
      
 0.497
FF38_06495
Putative vacuolar protein sorting-associated protein 18.
      
 0.440
FF38_00078
Uncharacterized protein.
     
 0.439
Your Current Organism:
Lucilia cuprina
NCBI taxonomy Id: 7375
Other names: Australian sheep blowfly, L. cuprina, greenbottle fly
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.