STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FF38_02795Putative tyrosyl-DNA phosphodiesterase. (581 aa)    
Predicted Functional Partners:
FF38_08634
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.945
FF38_13460
ATP-dependent DNA helicase 2 subunit 1.
     
 0.829
FF38_02842
DNA repair endonuclease XPF.
   
 
 0.779
FF38_03895
Ku domain-containing protein.
    
 0.771
FF38_10725
ERCC4 domain-containing protein.
   
 
 0.767
FF38_02531
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
   
 
 0.749
FF38_06416
Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.
   
 
 0.729
FF38_04306
FHA_2 domain-containing protein.
    
 
 0.699
FF38_08059
Exonuclease 1.
    
 
 0.681
FF38_04896
HHH_2 domain-containing protein.
    
 
 0.672
Your Current Organism:
Lucilia cuprina
NCBI taxonomy Id: 7375
Other names: Australian sheep blowfly, L. cuprina, greenbottle fly
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