STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
A0A1Y3NFT03-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (1082 aa)    
Predicted Functional Partners:
A0A1Y3MPG5
ACT domain-containing protein.
  
 0.928
A0A1Y3N5G5
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.910
A0A1Y3N3X5
Pyruvate carboxyltransferase domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.861
A0A1Y3NGE2
Putative 2-isopropylmalate synthase.
  
 0.861
A0A1Y3NGZ2
Pyruvate carboxyltransferase domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.861
A0A1Y3NA31
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
0.817
A0A1Y3NPB4
Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
  
0.813
A0A1Y3NNL9
Uncharacterized protein.
  
 
 0.802
A0A1Y3N1B9
Acetolactate synthase.
  
 0.801
A0A1Y3NJH2
Acetolactate synthase.
  
 0.801
Your Current Organism:
Piromyces sp. E2
NCBI taxonomy Id: 73868
Other names: P. sp. E2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.