STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGG81823.1Hypothetical protein. (162 aa)    
Predicted Functional Partners:
EGG79346.1
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 0.906
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.895
cmk
Cytidylate kinase.
    
  0.858
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
  
 0.803
EGG81825.1
Sua5/YciO/YrdC/YwlC family protein; Belongs to the SUA5 family.
       0.759
EGG81826.1
N-acetylmuramoyl-L-alanine amidase CwlD.
       0.708
EGG81827.1
Hypothetical protein.
       0.615
EGG81153.1
Pyrimidine-nucleoside phosphorylase.
    
 0.549
EGG79566.1
Uridine kinase.
    
 0.536
EGG84858.1
Epoxide hydrolase domain-like phosphatase.
  
 
  0.528
Your Current Organism:
Lachnospiraceae bacterium 2146FAA
NCBI taxonomy Id: 742723
Other names: L. bacterium 2_1_46FAA, Lachnospiraceae bacterium 2_1_46FAA
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.