| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EJZ61879.1 | EJZ62932.1 | HMPREF9448_02555 | HMPREF9448_02286 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.960 |
| EJZ61879.1 | EJZ63332.1 | HMPREF9448_02555 | HMPREF9448_01986 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.473 |
| EJZ61879.1 | EJZ63797.1 | HMPREF9448_02555 | HMPREF9448_01635 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | YbgI/family dinuclear metal center protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. | 0.704 |
| EJZ61879.1 | EJZ64919.1 | HMPREF9448_02555 | HMPREF9448_01405 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Por secretion system C-terminal sorting domain-containing protein. | 0.483 |
| EJZ61879.1 | EJZ66442.1 | HMPREF9448_02555 | HMPREF9448_00620 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Dihydropteroate synthase. | 0.996 |
| EJZ61879.1 | folE | HMPREF9448_02555 | HMPREF9448_00074 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | GTP cyclohydrolase I. | 0.867 |
| EJZ61879.1 | ribBA | HMPREF9448_02555 | HMPREF9448_02125 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Riboflavin biosynthesis protein ribBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.796 |
| EJZ61953.1 | EJZ62932.1 | HMPREF9448_02630 | HMPREF9448_02286 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.439 |
| EJZ61953.1 | EJZ63332.1 | HMPREF9448_02630 | HMPREF9448_01986 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.402 |
| EJZ61953.1 | EJZ66442.1 | HMPREF9448_02630 | HMPREF9448_00620 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydropteroate synthase. | 0.476 |
| EJZ61953.1 | folE | HMPREF9448_02630 | HMPREF9448_00074 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I. | 0.788 |
| EJZ61953.1 | ribBA | HMPREF9448_02630 | HMPREF9448_02125 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Riboflavin biosynthesis protein ribBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.722 |
| EJZ62932.1 | EJZ61879.1 | HMPREF9448_02286 | HMPREF9448_02555 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | 0.960 |
| EJZ62932.1 | EJZ61953.1 | HMPREF9448_02286 | HMPREF9448_02630 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.439 |
| EJZ62932.1 | EJZ63332.1 | HMPREF9448_02286 | HMPREF9448_01986 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.452 |
| EJZ62932.1 | EJZ63809.1 | HMPREF9448_02286 | HMPREF9448_01648 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Queuosine biosynthesis protein QueD. | 0.675 |
| EJZ62932.1 | EJZ64919.1 | HMPREF9448_02286 | HMPREF9448_01405 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Por secretion system C-terminal sorting domain-containing protein. | 0.762 |
| EJZ62932.1 | EJZ66442.1 | HMPREF9448_02286 | HMPREF9448_00620 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase. | 0.967 |
| EJZ62932.1 | folE | HMPREF9448_02286 | HMPREF9448_00074 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.964 |
| EJZ63332.1 | EJZ61879.1 | HMPREF9448_01986 | HMPREF9448_02555 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | 0.473 |