| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EJZ63003.1 | EJZ65385.1 | HMPREF9448_02360 | HMPREF9448_00766 | Hypothetical protein. | Alpha,alpha-trehalose-phosphate synthase (UDP-forming). | 0.877 |
| EJZ63003.1 | phnX | HMPREF9448_02360 | HMPREF9448_01021 | Hypothetical protein. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.503 |
| EJZ63332.1 | guaA | HMPREF9448_01986 | HMPREF9448_00375 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.788 |
| EJZ63332.1 | guaB | HMPREF9448_01986 | HMPREF9448_01329 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.809 |
| EJZ63332.1 | phnX | HMPREF9448_01986 | HMPREF9448_01021 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.675 |
| EJZ64542.1 | phnW | HMPREF9448_01020 | HMPREF9448_01022 | Hypothetical protein. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.748 |
| EJZ64542.1 | phnX | HMPREF9448_01020 | HMPREF9448_01021 | Hypothetical protein. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.807 |
| EJZ64814.1 | phnX | HMPREF9448_01300 | HMPREF9448_01021 | Competence/damage-inducible protein CinA domain; Belongs to the CinA family. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.698 |
| EJZ65129.1 | phnW | HMPREF9448_00859 | HMPREF9448_01022 | Hypothetical protein. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.797 |
| EJZ65129.1 | phnX | HMPREF9448_00859 | HMPREF9448_01021 | Hypothetical protein. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.682 |
| EJZ65385.1 | EJZ63003.1 | HMPREF9448_00766 | HMPREF9448_02360 | Alpha,alpha-trehalose-phosphate synthase (UDP-forming). | Hypothetical protein. | 0.877 |
| EJZ65385.1 | phnX | HMPREF9448_00766 | HMPREF9448_01021 | Alpha,alpha-trehalose-phosphate synthase (UDP-forming). | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.789 |
| guaA | EJZ63332.1 | HMPREF9448_00375 | HMPREF9448_01986 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.788 |
| guaA | guaB | HMPREF9448_00375 | HMPREF9448_01329 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | hisB | HMPREF9448_00375 | HMPREF9448_01913 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.562 |
| guaA | phnX | HMPREF9448_00375 | HMPREF9448_01021 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.717 |
| guaB | EJZ63332.1 | HMPREF9448_01329 | HMPREF9448_01986 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.809 |
| guaB | guaA | HMPREF9448_01329 | HMPREF9448_00375 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | hisB | HMPREF9448_01329 | HMPREF9448_01913 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.541 |
| guaB | phnX | HMPREF9448_01329 | HMPREF9448_01021 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. | 0.686 |