| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EJZ61953.1 | EJZ64655.1 | HMPREF9448_02630 | HMPREF9448_01136 | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.614 |
| EJZ63261.1 | EJZ64655.1 | HMPREF9448_01910 | HMPREF9448_01136 | Hypothetical protein. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.732 |
| EJZ63261.1 | EJZ65226.1 | HMPREF9448_01910 | HMPREF9448_00957 | Hypothetical protein. | MtaA/CmuA family methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. | 0.690 |
| EJZ63380.1 | EJZ64655.1 | HMPREF9448_02036 | HMPREF9448_01136 | Hypothetical protein. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.461 |
| EJZ63380.1 | EJZ66457.1 | HMPREF9448_02036 | HMPREF9448_00635 | Hypothetical protein. | Pyruvate:ferredoxin (flavodoxin) oxidoreductase. | 0.999 |
| EJZ64654.1 | EJZ64655.1 | HMPREF9448_01135 | HMPREF9448_01136 | Translation elongation factor G. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.561 |
| EJZ64655.1 | EJZ61953.1 | HMPREF9448_01136 | HMPREF9448_02630 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.614 |
| EJZ64655.1 | EJZ63261.1 | HMPREF9448_01136 | HMPREF9448_01910 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hypothetical protein. | 0.732 |
| EJZ64655.1 | EJZ63380.1 | HMPREF9448_01136 | HMPREF9448_02036 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hypothetical protein. | 0.461 |
| EJZ64655.1 | EJZ64654.1 | HMPREF9448_01136 | HMPREF9448_01135 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Translation elongation factor G. | 0.561 |
| EJZ64655.1 | EJZ64869.1 | HMPREF9448_01136 | HMPREF9448_01355 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hypothetical protein. | 0.421 |
| EJZ64655.1 | EJZ65226.1 | HMPREF9448_01136 | HMPREF9448_00957 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | MtaA/CmuA family methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. | 0.632 |
| EJZ64655.1 | EJZ66457.1 | HMPREF9448_01136 | HMPREF9448_00635 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pyruvate:ferredoxin (flavodoxin) oxidoreductase. | 0.649 |
| EJZ64655.1 | hflX | HMPREF9448_01136 | HMPREF9448_01939 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.423 |
| EJZ64655.1 | miaB | HMPREF9448_01136 | HMPREF9448_02588 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | (Dimethylallyl)adenosine tRNA methylthiotransferase miaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.437 |
| EJZ64655.1 | rlmN | HMPREF9448_01136 | HMPREF9448_00518 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 23S rRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. | 0.632 |
| EJZ64869.1 | EJZ64655.1 | HMPREF9448_01355 | HMPREF9448_01136 | Hypothetical protein. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.421 |
| EJZ65226.1 | EJZ63261.1 | HMPREF9448_00957 | HMPREF9448_01910 | MtaA/CmuA family methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. | Hypothetical protein. | 0.690 |
| EJZ65226.1 | EJZ64655.1 | HMPREF9448_00957 | HMPREF9448_01136 | MtaA/CmuA family methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.632 |
| EJZ66457.1 | EJZ63380.1 | HMPREF9448_00635 | HMPREF9448_02036 | Pyruvate:ferredoxin (flavodoxin) oxidoreductase. | Hypothetical protein. | 0.999 |