Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EGX68826.1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)    
Predicted Functional Partners:
adk
Hypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
 
 0.956
EGX67088.1
Hypothetical protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 0.954
ade
Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
 
  
 0.941
guaA
Hypothetical protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.939
EGX70985.1
Purine nucleoside phosphorylase.
     
 0.934
ftsH-2
Hypothetical protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.933
EGX67571.1
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.918
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.918
EGX67519.1
Inosine-5'-monophosphate dehydrogenase.
    
 0.910
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
  
 
 0.905
Your Current Organism:
Collinsella tanakaei
NCBI taxonomy Id: 742742
Other names: C. tanakaei YIT 12063, Collinsella sp. YIT 12063, Collinsella tanakaei JCM 16071, Collinsella tanakaei YIT 12063, Collinsella tanakaei str. YIT 12063, Collinsella tanakaei strain YIT 12063
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.