STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (243 aa)    
Predicted Functional Partners:
AEG43593.1
KEGG: xce:Xcel_0757 exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; PFAM: Endonuclease/exonuclease/phosphatase.
 
 0.967
AEG43102.1
KEGG: xce:Xcel_3155 exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; PFAM: Endonuclease/exonuclease/phosphatase.
  
 0.686
AEG43333.1
KEGG: xce:Xcel_0394 HhH-GPD family protein; PFAM: HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif; SMART: HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif.
 
  
0.675
AEG44513.1
PFAM: NUDIX hydrolase domain; KEGG: xce:Xcel_1901 NUDIX hydrolase; Belongs to the Nudix hydrolase family.
    
 0.675
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.659
AEG45399.1
KEGG: xce:Xcel_3038 Crp/Fnr family transcriptional regulator; PFAM: Cyclic nucleotide-binding; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding; HTH transcriptional regulator, Crp.
       0.640
AEG45599.1
Deoxyribonuclease IV (phage-T(4)-induced); PFAM: Xylose isomerase, TIM barrel domain; KEGG: xce:Xcel_3293 xylose isomerase domain-containing protein; SMART: Endodeoxyribonuclease IV.
  
 
 0.634
AEG44011.1
DNA-(apurinic or apyrimidinic site) lyase; KEGG: xce:Xcel_1239 DNA glycosylase/AP lyase, H2TH DNA-binding protein; PFAM: DNA glycosylase/AP lyase, catalytic domain; DNA glycosylase/AP lyase, H2TH DNA-binding.
   
  
 0.582
AEG43852.1
PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; DNA glycosylase/AP lyase, catalytic domain; KEGG: xce:Xcel_1106 DNA glycosylase/AP lyase, H2TH DNA-binding protein; Belongs to the FPG family.
   
  
 0.581
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.565
Your Current Organism:
Isoptericola variabilis
NCBI taxonomy Id: 743718
Other names: I. variabilis 225, Isoptericola variabilis 225, Isoptericola variabilis str. 225, Isoptericola variabilis strain 225
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