node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKA73330.1 | SKA74083.1 | SAMN02745178_00135 | SAMN02745178_00259 | 4-hydroxy 2-oxovalerate aldolase. | Acetolactate synthase, small subunit. | 0.906 |
SKA73330.1 | SKA74087.1 | SAMN02745178_00135 | SAMN02745178_00260 | 4-hydroxy 2-oxovalerate aldolase. | Acetolactate synthase, large subunit. | 0.721 |
SKA73330.1 | SKA88898.1 | SAMN02745178_00135 | SAMN02745178_01891 | 4-hydroxy 2-oxovalerate aldolase. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.721 |
SKA73330.1 | SKA94758.1 | SAMN02745178_00135 | SAMN02745178_02532 | 4-hydroxy 2-oxovalerate aldolase. | Glutamate synthase (ferredoxin). | 0.546 |
SKA73330.1 | ilvC | SAMN02745178_00135 | SAMN02745178_00258 | 4-hydroxy 2-oxovalerate aldolase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.828 |
SKA73330.1 | ilvD | SAMN02745178_00135 | SAMN02745178_00257 | 4-hydroxy 2-oxovalerate aldolase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.940 |
SKA73330.1 | leuB | SAMN02745178_00135 | SAMN02745178_01263 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.842 |
SKA73330.1 | leuC | SAMN02745178_00135 | SAMN02745178_01265 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.946 |
SKA73330.1 | leuD | SAMN02745178_00135 | SAMN02745178_01264 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.950 |
SKA74083.1 | SKA73330.1 | SAMN02745178_00259 | SAMN02745178_00135 | Acetolactate synthase, small subunit. | 4-hydroxy 2-oxovalerate aldolase. | 0.906 |
SKA74083.1 | SKA74087.1 | SAMN02745178_00259 | SAMN02745178_00260 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SKA74083.1 | SKA88898.1 | SAMN02745178_00259 | SAMN02745178_01891 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.995 |
SKA74083.1 | SKA94758.1 | SAMN02745178_00259 | SAMN02745178_02532 | Acetolactate synthase, small subunit. | Glutamate synthase (ferredoxin). | 0.714 |
SKA74083.1 | ilvC | SAMN02745178_00259 | SAMN02745178_00258 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SKA74083.1 | ilvD | SAMN02745178_00259 | SAMN02745178_00257 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.957 |
SKA74083.1 | leuA | SAMN02745178_00259 | SAMN02745178_01266 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.932 |
SKA74083.1 | leuB | SAMN02745178_00259 | SAMN02745178_01263 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.945 |
SKA74083.1 | leuC | SAMN02745178_00259 | SAMN02745178_01265 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.833 |
SKA74083.1 | leuD | SAMN02745178_00259 | SAMN02745178_01264 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.867 |
SKA74087.1 | SKA73330.1 | SAMN02745178_00260 | SAMN02745178_00135 | Acetolactate synthase, large subunit. | 4-hydroxy 2-oxovalerate aldolase. | 0.721 |